EFFECTS OF THE NONPEPTIDE INHIBITOR OPC-21268 ON OXYTOCIN AND VASOPRESSIN STIMULATION OF RAT AND HUMAN MYOMETRIUM

Authors
ATKE A VILHARDT H HAUZEROVA L BARTH T ANDERSEN LF
Citation
A. Atke et al., EFFECTS OF THE NONPEPTIDE INHIBITOR OPC-21268 ON OXYTOCIN AND VASOPRESSIN STIMULATION OF RAT AND HUMAN MYOMETRIUM, European journal of pharmacology, 281(1), 1995, pp. 63-68
Citations number
38
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
281
Issue
1
Year of publication
1995
Pages
63 - 68
Database
ISI
SICI code
0014-2999(1995)281:1<63:EOTNIO>2.0.ZU;2-0
Abstract
OPC-21268 enzoyl]-piperidyl]-3,4-dihydro-2(1H)-quinolinone), a non-pep tide vasopresssin V-1 receptor antagonist, inhibited oxytocin- and vas opressin-induced contractions of myometrial strips from rats and from full-term pregnant women. Administered intravenously in rats the drug also inhibited uterine contractions caused by infusion of oxytocin. Wh en incubated with purified plasma membranes from rat or human myometri al tissue, OPC-21268 inhibited the specific receptor binding of tritia ted oxytocin and vasopressin in a dose-dependent and reversible way.