CORRELATION OF TC-99M GSA HEPATIC STUDIES WITH BIOPSIES IN PATIENTS WITH CHRONIC ACTIVE HEPATITIS

To determine whether scintigraphic findings of Tc-99m DTPA-galactosyl- HSA (GSA) correspond to histopathologic findings, Tc-99m GSA hepatic s cintigraphy and biopsy were compared in 65 patients with chronic activ e hepatitis. After injecting 185 MBq of Tc-99m GSA, anterior images we re obtained at 5 minutes and 15 minutes. Scintigrams were classified i nto three grades according to the extent of visualization of the cardi ac blood pool on 5 minute and 15 minute images, Biopsies were subjecti vely graded for findings of necrosis and fibrosis, Scintigraphic grade s on 5 minute images were correlated with hepatic necrosis and fibrosi s and those on 15-minute images with hepatic fibrosis, Scintigraphic a bnormalities of Tc-99m GSA correlated well with histopathologic abnorm alities, especially with hepatic fibrosis and necrosis in patients wit h chronic active hepatitis.