STABILITY OF IFOSFAMIDE IN SOLUTIONS FOR MULTIDAY INFUSION BY EXTERNAL PUMP

The stability of ifosfamide in Ringer lactate buffer solution either a lone or mixed with mesna at 37 degrees C for a 7-day period was analyz ed by HPLC, This study was performed to investigate the feasibility of continuous infusion of ifosfamide by a multiday pump in order to redu ce the toxicity and to increase the production of active alkylating me tabolites of the parent drug. The total decay of ifosfamide activity d id not exceed 3.2% at day 7, We conclude that ifosfamide can be safely delivered in a 7-day infusion with no significant loss of activity.