BIOTRANSFORMATION OF (-)-ALPHA-BISABOLOL BY PLANT-PATHOGENIC FUNGUS, GLOMERELLA-CINGULATA

Microbial transformation of (-)-alpha-bisabolol by Glomerella cingulat a has been investigated. (-)-alpha-Bisabolol was initially transformed to (1S,3R,4R,7S)-3,4-dihydroxy-alpha-bisabolol and bisabolol oxide B. (1S,3R,4R,7S)-3,4-Dihydroxy-alpha-bisabolol was further transformed t o (1S,3R,4R,7S,10S)-3,4-dihydroxy-bisabolo oxide B. Bisabolol oxide B was also further transformed to (1S,3R,4R,7S,10S)- and (1S,3S,4S,7S,10 S)-3,4-dihydroxy-bisabolo oxide B. The structures of the metabolic pro ducts were determined by spectroscopic methods. Metabolic pathways of the biotransformation of (-)-alpha-bisabolol by G. cingulata are also discussed.