ANONYCHIA AND ABSENCE HYPOPLASIA OF DISTAL PHALANGES (COOKS-SYNDROME)- REPORT OF A 2ND FAMILY

We describe a second family with four affected members in three succes sive generations with a rare nail dysplasia syndrome. The syndrome, wh ich was first reported by Cooks et al in 1985, is characterised by bil ateral nail hypoplasia of digits 1-3, with absence of nails of digits 4-5 of the hands, and total absence of all toe nails. In addition, the re is absence/hypoplasia of the distal phalanges of the hands and feet . Our family confirms this syndrome as a distinct entity with autosoma l dominant inheritance.