Free radical and nonfree radical oxidants can produce damaging effects
in animal tissues if antioxidants are deficient. These oxidants are p
roduced during metabolism and may be substantially increased by aerobi
c exercise, stress, tissue injury, infection, and detoxification of ma
ny compounds. Stress may precede an infectious episode in animals by d
ecreasing antioxidants needed later by an active immune response. Anti
oxidant nutrients such as vitamin E, beta-carotene and the trace eleme
nts selenium, copper, zinc and manganese in enzymes are very important
in protecting an animal's tissues from oxidative destruction. This pr
otective benefit also results in an improved immune response which dec
reases mastitis in dairy cows and infectious disease incidences arisin
g in stressed cattle following shipping. The amount of nutrients neede
d for immunoenhancement is higher than the suggested required amounts
by NRC.