Z. Ovadia et al., NONINVASIVE EVALUATION OF MICROCIRCULATORY HEMODYNAMIC-CHANGES DURINGHEMORRHAGE FOLLOWED BY SALINE OR BLOOD-TRANSFUSION, Shock, 4(2), 1995, pp. 96-101
The purpose of the study was to examine the ability of a system combin
ing laser Doppler flowmetry (LDF), photoplethysmograph (PPG), and tran
scutaneous oxygen tension (tc-PO2) to follow changes in the microcircu
lation during hemorrhage and following blood or saline return, and to
test the hypothesis that such changes precede and might predict change
s in the systemic blood pressure. Measurements were performed on the s
kin of anesthetized rabbits (n = 10) during mild (0-8%), moderate (9-2
4%), and severe (25-30% of blood volume) hemorrhage, and following com
plete volume restitution by blood or saline. We found the following: 1
) hemorrhage caused typical changes in the LDF, PPG, and tc-PO2, signa
ls that could be formulated by mathematical models, 2) these signals i
dentified blood as being more efficient than saline for volume restitu
tion following hemorrhage, and 3) microcirculatory changes precede and
might predict systemic hemodynamic events.