HYPEROSMOTIC GLUCOSE-INFUSION DURING HEMORRHAGE DOES NOT REDUCE BACTERIAL TRANSLOCATION IN 24 HOUR-STARVED RATS

Food deprivation 24 h before stress increases bacterial translocation in hemorrhage. Presently it tested whether hyperosmolality, induced by exogenous glucose infusion to improve plasma refill, prevents or redu ces bacterial translocation after experimental hemorrhage in 24 h food -deprived rats. Rats were given an i.v. infusion of either 2 mL of 30% glucose (G) or the same volume of .9% NaCl (C) while simultaneously b eing submitted to a standardized 60 min hemorrhage period, of moderate or more severe hemorrhage. Blood was not reinfused. Despite developme nt of marked hyperglycemia (p < .001, G vs. C) resulting in significan tly greater reductions in packed cell volume (p < .001, G vs. C), bact erial translocation was detected similarly in both groups regardless o f whether moderate (10/12-G, 9/12-C) or severe (15/19-G, 15/18-C) hemo rrhage was inflicted. It was concluded that hyperglycemic hyperosmolal ity did not prevent bacterial translocation in these models of hemorrh agic stress in 24 h-starved rats.