IOTROLAN, A NONIONIC DIMERIC CONTRAST AGENT IN CEREBRAL-ANGIOGRAPHY

We report the European experience with iotrolan 280, a new, non-ionic, isotonic, dimeric, iodinated contrast agent in cerebral angiography. Six randomized, double-blind, controlled, interindividual studies took place at four study centers in Germany. All the studies used intra-ar terial contrast administration; iotrolan 280 was administered to 186 p atients, iopamidol 300 to 127 patients, iohexol 300 to 30 patients and iopromide 300 to 30 patients. Iotrolan 280 gave improved contrast qua lity with improved opacification of small cerebral vessels. Local pain and heat sensations were fewer following iotrolan administration. The re was a trend towards better neural tolerance of iotrolan 280 as show n by electroencephalogram.