The safety, tolerance and efficacy of the non-ionic dimer iotrolan 280
in head and body computed tomography was compared with iohexol, iopam
idol iopromide ina double-blind, randomized, multicenter study. A tota
l of 307 head and 261 body examinations were performed. No significant
changes in liver or renal blood parameters were seen up to 24 h post-
examination. No significant differences in tolerability, adverse event
s profile, and efficacy were seen.