RENAL TOLERANCE OF IOTROLAN-280 - A METAANALYSIS OF 14 DOUBLE-BLIND STUDIES

Clinical data from 14 randomized, double-blind studies were reviewed t o compare the renal tolerance of non-ionic monomeric contrast agents ( iopamidol 300, iopromide 300, iohexol 300) with the non-ionic dimer io trolan 280. A prospective study of iotrolan 280 versus iohexol 300 in renally impaired patients was also evaluated. Differences between the contrast agents were investigated using sub-group analysis of patients with an increased risk of contrast-induced nephropathy. Both the pros pective study and meta-analysis of previous studies indicate that iotr olan 280 has less influence on renal function than the non-ionic monom eric comparator agents.