OCCURRENCE OF THE CYS311 DRD2 VARIANT IN A PEDIGREE MULTIPLY AFFECTEDWITH PANIC DISORDER

Following the detection of the rare DRD2 codon 311 variant (Ser-->Cys) in an affected member from a large, multiply affected panic disorder family, we investigated the occurrence of this variant in other family members, The variant occurred in both affected and unaffected individ uals. Further screening in panic disorder sib pairs unrelated to this family failed to detect the Cys311 variant, Our data suggests that thi s variant has no pathogenic role in panic disorder, (C) 1995 Wiley-Lis s, Inc.