SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ELECTRON-RICH OLEFIN DERIVED CYCLIC UREAS

Seventeen cyclic ureas containing imidazolidine and benzimidazoline nu clei were synthesised by the reaction of electron-rich olefins with ap propriate group 16 elements (O, S, Se, Te). The compounds synthesised were identified by H-1, C-13-NMR, FT-IR and mass spectroscopic techniq ues and micro analysis. All compounds studied in this work were screen ed for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213 ), Escherichia coli (ATCC) 25922) and Pseudomonas aeruginosa (ATCC 278 53). Eight of the compounds were found effective to inhibit the growth of Gram-positive bacteria (Enterococcus Faecalis and Staphylococcus a ureus) at MIC values between 25-400 mu g/ml. None of the compounds exh ibit antimicrobial activity against gram-negative bacteria (Escherichi a coli; and Pseudmonas aeruginosa) at the concentrations studied (6.25 -800 mu g/ml).