Ls. Trukhanova et Vs. Turusov, SARCOMATOUS LESIONS IN CBA FEMALE MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE - INDEPENDENT PRIMARIES OR METASTASES, Clinical & experimental metastasis, 13(5), 1995, pp. 389-395
CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in c
ombination with oestradiol dipropionate (EP) or ascorbic acid (AA) dev
eloped, as expected, a high incidence of uterine sarcomas. In addition
, sarcomatous lesions at unusual sites (mainly in the forestomach) wer
e evident. The incidence of sarcomatous lesions at other sites was 53/
220 in mice having uterine sarcomas and 0/186 in mice treated with DMH
but without uterine sarcomas, The difference between the two groups w
as highly statistically significant (P<0.001) and demonstrates non-coi
ncidental association of the above sarcomatous lesions with uterine sa
rcomas, Uterine sarcomas which presented in association with lesions a
t other sites were of a larger size than those found in isolation, and
the difference in weights in three out of four groups was statistical
ly significant (P=0.008, 0.035 and 0.011), Histologically, sarcomatous
lesions were similar in structure to those of uterine sarcomas, i,e,
were of a fibroblastic-histiocytic nature with admixture of giant cell
s. On the basis of the above data the sarcomatous lesions described ap
pear to represent uterine sarcoma metastases rather than independent p
rimary tumours. AA did not have any influence on carcinogenesis induce
d by DMH alone but inhibited the growth of uterine sarcomas (whether o
r not they were associated with other sarcomatous lesions) induced by
DMH combined with oestradiol dipropionate.