SARCOMATOUS LESIONS IN CBA FEMALE MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE - INDEPENDENT PRIMARIES OR METASTASES

Citation
Ls. Trukhanova et Vs. Turusov, SARCOMATOUS LESIONS IN CBA FEMALE MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE - INDEPENDENT PRIMARIES OR METASTASES, Clinical & experimental metastasis, 13(5), 1995, pp. 389-395
Citations number
11
Categorie Soggetti
Oncology
ISSN journal
02620898
Volume
13
Issue
5
Year of publication
1995
Pages
389 - 395
Database
ISI
SICI code
0262-0898(1995)13:5<389:SLICFM>2.0.ZU;2-C
Abstract
CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in c ombination with oestradiol dipropionate (EP) or ascorbic acid (AA) dev eloped, as expected, a high incidence of uterine sarcomas. In addition , sarcomatous lesions at unusual sites (mainly in the forestomach) wer e evident. The incidence of sarcomatous lesions at other sites was 53/ 220 in mice having uterine sarcomas and 0/186 in mice treated with DMH but without uterine sarcomas, The difference between the two groups w as highly statistically significant (P<0.001) and demonstrates non-coi ncidental association of the above sarcomatous lesions with uterine sa rcomas, Uterine sarcomas which presented in association with lesions a t other sites were of a larger size than those found in isolation, and the difference in weights in three out of four groups was statistical ly significant (P=0.008, 0.035 and 0.011), Histologically, sarcomatous lesions were similar in structure to those of uterine sarcomas, i,e, were of a fibroblastic-histiocytic nature with admixture of giant cell s. On the basis of the above data the sarcomatous lesions described ap pear to represent uterine sarcoma metastases rather than independent p rimary tumours. AA did not have any influence on carcinogenesis induce d by DMH alone but inhibited the growth of uterine sarcomas (whether o r not they were associated with other sarcomatous lesions) induced by DMH combined with oestradiol dipropionate.