PUTATIVE ATYPICAL ANTIPSYCHOTICS WITH MIXED DOPAMINERGIC (D-1, D-2) AND SEROTONERGIC (5HT(2)) ACTIVITY - THE DESIGN EVOLUTION OF ZD3638

Authors
KLIMAS MT GOLDSTEIN JM TRAINOR DA JACOBS RT OHNMACHT CJ ROBERTS RA YEE YK TERPKO MO THOMAS SP CRONK LA FRANK CA HARRIS GD HULSIZER J LEWIS JJ MCLAREN FM MAUGER RC MOROSKY GD RONKIN SM SIENKEWICZ P SPARKS RB ULATOWSKI TG WILDONGER D
Citation
Mt. Klimas et al., PUTATIVE ATYPICAL ANTIPSYCHOTICS WITH MIXED DOPAMINERGIC (D-1, D-2) AND SEROTONERGIC (5HT(2)) ACTIVITY - THE DESIGN EVOLUTION OF ZD3638, Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1795-1800
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1795 - 1800
Database
ISI
SICI code
0960-894X(1995)5:16<1795:PAAWMD>2.0.ZU;2-C
Abstract
The pharmacological activity of a series of 9,10-dihydro-9,10-methanoa nthracene methylene amines which function as mixed dopaminergic (D-1/D -2) and serotonergic (5HT(2)) antagonists is described. The work resul ted in a putative atypical antipsychotic, ZD3638, of novel structure a nd pharmacological profile.