1-NAPHTHYLMETHYLPHOSPHONIC ACID-DERIVATIVES AS OSTEOCLASTIC ACID-PHOSPHATASE INHIBITORS

Authors
SCHWENDER CF BEERS SA MALLOY E DEMAREST K MINOR L LAU KHW
Citation
Cf. Schwender et al., 1-NAPHTHYLMETHYLPHOSPHONIC ACID-DERIVATIVES AS OSTEOCLASTIC ACID-PHOSPHATASE INHIBITORS, Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1801-1806
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1801 - 1806
Database
ISI
SICI code
0960-894X(1995)5:16<1801:1AAOA>2.0.ZU;2-8
Abstract
Inhibition of the enzyme, osteoclastic acid phosphatase (OAP) may be a viable approach to the treatment of osteoporosis. A series of arylmet hylphosphonic acids were synthesized and shown to be inhibitors of OAP . The most potent inhibitor, bis-benzoyl-1-naphthylmethylphosphonic ac id (7a) had an IC50 = 1.4 mu M.