N-(1-PHENYL-2-BENZIMIDAZOLYL)-N'-PHENYLUREA DERIVATIVES AS POTENT INHIBITORS OF ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT)

Authors
KUMAZAWA T HARAKAWA H FUKUI H SHIRAKURA S OHISHI E YAMADA K
Citation
T. Kumazawa et al., N-(1-PHENYL-2-BENZIMIDAZOLYL)-N'-PHENYLUREA DERIVATIVES AS POTENT INHIBITORS OF ACYL-COA-CHOLESTEROL ACYLTRANSFERASE (ACAT), Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1829-1832
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1829 - 1832
Database
ISI
SICI code
0960-894X(1995)5:16<1829:NDAPI>2.0.ZU;2-#
Abstract
A navel series of N-(1-phenyl-2-benzimidazolyl)-N'-phenylurea derivati ves were prepared as ACAT inhibitors. These compounds showed potent AC AT inhibitory activity in vitro (liver microsomes from cholesterol-fed rabbits) and hypocholesterolemic activity in vivo (cholesterol-fed go lden hamsters).