4-(2-PYRIDYL)-2,2-DIMETHYLNAPHTHALEN-1-ONES AS NEW POTASSIUM CHANNEL ACTIVATORS WITH INCREASED AIRWAYS SELECTIVITY

Authors
ALMANSA C GOMEZ LA CAVALCANTI FL RODRIGUEZ R GARCIARAFANELL J FORN J
Citation
C. Almansa et al., 4-(2-PYRIDYL)-2,2-DIMETHYLNAPHTHALEN-1-ONES AS NEW POTASSIUM CHANNEL ACTIVATORS WITH INCREASED AIRWAYS SELECTIVITY, Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1833-1838
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1833 - 1838
Database
ISI
SICI code
0960-894X(1995)5:16<1833:4ANPCA>2.0.ZU;2-5
Abstract
A new series of 4-(2-pyridyl)-2,2-dimethylnaphthalen-1-one potassium c hannel activators has been prepared and their in vitro relaxant activi ties in isolated rat portal vein and guinea-pig tracheal spirals as we ll as their hypotensive and bronchodilatory effects have been evaluate d. Oxidation of the pyridyl nitrogen atom and a double bond between po sitions 3 and 4 provide compounds with some degree of airways selectiv ity.