2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)

Authors
FUJITA T HIROSE R HAMAMICHI N KITAO Y SASAKI S YONETA M CHIBA K
Citation
T. Fujita et al., 2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN), Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1857-1860
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1857 - 1860
Database
ISI
SICI code
0960-894X(1995)5:16<1857:22-MES>2.0.ZU;2-Z
Abstract
2-Substituted 2-aminoethanol was shown to be the minimum essential str ucture for the immunosuppressive activity of ISP-I (myriocin, thermozy mocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, w hich was generated by modification of ISP-I. Among the series, 2-amino -4-(4-octylphenyl)butanol hydrochloride displayed comparably potent ac tivity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochlo ride, FTY720.