THE IN-VITRO CYTOTOXICITY AND DNA ALKYLATING ABILITY OF THE SIMPLEST FUNCTIONAL ANALOGS OF THE SECO CC-1065 ALKYLATING SUBUNIT

Authors
WHITE RH PARSONS PG PRAKASH AS YOUNG DJ
Citation
Rh. White et al., THE IN-VITRO CYTOTOXICITY AND DNA ALKYLATING ABILITY OF THE SIMPLEST FUNCTIONAL ANALOGS OF THE SECO CC-1065 ALKYLATING SUBUNIT, Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1869-1874
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1869 - 1874
Database
ISI
SICI code
0960-894X(1995)5:16<1869:TICADA>2.0.ZU;2-X
Abstract
The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural r equirements for alkylating DNA with Ar-3' participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity wh ich is diminished relative to more functionalised seco analogues of th e antitumor agent CC-1065 alkylating subunit.