DESIGN AND SYNTHESIS OF A CONFORMATIONALLY CONSTRAINED ANALOG OF THE BIS(HETEROARYL)PIPERAZINE (BHAP) HIV-1 REVERSE-TRANSCRIPTASE INHIBITORATEVIRDINE

Authors
GENIN MJ CHIDESTER CG ROHRER DC ROMERO DL
Citation
Mj. Genin et al., DESIGN AND SYNTHESIS OF A CONFORMATIONALLY CONSTRAINED ANALOG OF THE BIS(HETEROARYL)PIPERAZINE (BHAP) HIV-1 REVERSE-TRANSCRIPTASE INHIBITORATEVIRDINE, Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1875-1880
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
16
Year of publication
1995
Pages
1875 - 1880
Database
ISI
SICI code
0960-894X(1995)5:16<1875:DASOAC>2.0.ZU;2-D
Abstract
The design and synthesis of a novel conformationally constrained spiro analog of the BHAP class of HIV-1 reverse transcriptase inhibitors, b ased on the molecular modeling and the X-ray crystal structure of the clinical candidate atevirdine, is described.