Km. Sivanandaiah et al., SYNTHETIC PEPTIDES RELATED TO THE DELTA-RECEPTOR AGONIST, DERMORPHIN GENE ASSOCIATED PEPTIDE, Indian Journal of Biochemistry & Biophysics, 32(4), 1995, pp. 196-199
The delta-receptor selective dermorphin gene associated peptide (DGAP)
and five of its analogues having structural modifications at position
s 2, 4 and 5 were synthesized by the solid phase method using 9-fluore
nylmethoxycarbonyl amino acid trichlorophenyl esters as coupling agent
s and p- benzyloxybenzyl alcohol resin as the solid support. The delta
-receptor selectivity of these peptides was determined by guinea pig i
leum and mouse vas deferens assays. The latter assay was carried out u
sing modified Kreb's solution aerated with pure oxygen instead of carb
ogen. All the synthetic peptides were found to be delta-receptor selec
tive.