N. Jaffe et al., CHEMOTHERAPY IN OSTEOSARCOMA - BASIS FOR APPLICATION AND ANTAGONISM TO IMPLEMENTATION - EARLY CONTROVERSIES SURROUNDING ITS IMPLEMENTATION, Hematology/oncology clinics of North America, 9(4), 1995, pp. 825-840
Chemotherapy in osteosarcoma has had a major impact in attaining metas
tasis-free survival, and the cure rates with the use of modern regimen
s range from 65% to 75%. Preoperative chemotherapy has facilitated sur
gical resection of the primary tumor, rendering increased numbers of c
andidates for limb salvage. The effects on the primary tumor may be us
ed as a predictive factor in determining outcome.