IN-VIVO EVALUATION OF PINDOLOL MULTIUNIT DOSAGE FORMS

Pindolol, a beta adrenoceptor agent, is effective in the treatment of hypertension in daily doses ranging from 10 to 45 mg. The drug shows p H dependent solubility and a modified multi unit controlled release fo rmulation was assessed for efficacy in vivo in healthy male human volu nteers. An open blind comparative crossover study of the controlled re lease formulation was carried out with a conventional formulation. The treated quotients and the ratio between the maximal plasma concentrat ion were calculated to assess the efficacy of the formulations.