Th. Grenby, DENTAL PROPERTIES OF ANTISEPTIC THROAT LOZENGES FORMULATED WITH SUGARS OR LYCASIN, Journal of clinical pharmacy and therapeutics, 20(4), 1995, pp. 235-241
Thirteen different formulations of throat lozenges were examined for t
heir acidity, demineralizing action on hydroxylapatite, and fermentabi
lity by human dental plaque micro-organisms, Their flavouring acids ga
ve them low pH values in the range 2.6-3.7, leading to the dissolution
of calcium and phosphorus from hydroxylapatite. The combination of an
tiseptics and flavouring acids in the lozenges inhibited microbial gro
wth and metabolism. In the absence of any antiseptics and flavouring a
cids, the growth and metabolic activity of cultures of plaque micro-or
ganisms were significantly greater on sucrose + glucose lozenges than
on a new Lycasin formulation.