DEGRADATION OF VITRONECTIN BY MATRIX METALLOPROTEINASE-1, METALLOPROTEINASE-2, METALLOPROTEINASE-3, METALLOPROTEINASE-7 AND METALLOPROTEINASE-9

Authors
IMAI K SHIKATA H OKADA Y
Citation
K. Imai et al., DEGRADATION OF VITRONECTIN BY MATRIX METALLOPROTEINASE-1, METALLOPROTEINASE-2, METALLOPROTEINASE-3, METALLOPROTEINASE-7 AND METALLOPROTEINASE-9, FEBS letters, 369(2-3), 1995, pp. 249-251
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
369
Issue
2-3
Year of publication
1995
Pages
249 - 251
Database
ISI
SICI code
0014-5793(1995)369:2-3<249:DOVBMM>2.0.ZU;2-D
Abstract
The susceptibility of vitronectin (Vn) purified from human plasma to d igestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesti ng 8-, 30-and 44-fold more preferentially than MMP-2, -3 and -9, respe ctively. These data suggest that MMP-2, -3, -7 and -9 may be responsib le for the pathological degradation and/or normal turnover of Vn.