EFFECTS OF DERMAL EXPOSURE TO PARAPHENYLENEDIAMINE IN GUINEA-PIGS

Authors
MATHUR AK GUPTA BN SINGH S SINGH A
Citation
Ak. Mathur et al., EFFECTS OF DERMAL EXPOSURE TO PARAPHENYLENEDIAMINE IN GUINEA-PIGS, Journal of toxicology. Cutaneous and ocular toxicology, 14(3), 1995, pp. 207-210
Citations number
15
Categorie Soggetti
Toxicology
Journal title
Journal of toxicology. Cutaneous and ocular toxicology → ACNP
ISSN journal
07313829
Volume
14
Issue
3
Year of publication
1995
Pages
207 - 210
Database
ISI
SICI code
0731-3829(1995)14:3<207:EODETP>2.0.ZU;2-N
Abstract
Guinea pigs were dermally exposed to the hairdye paraphenylenediamine (PPD) for 15 and 30 days to assess the effects on selected enzyme acti vities, lipid peroxidation, and histamine content in the skin. The act ivities of acid phosphatase, glutathione-s-transferase, and tyrosinase were enhanced after application of PPD. The lipid peroxidation, hista mine, and PPD content of skin also showed marked elevation following d ermal exposure to the chemical.