EFFECT OF MODIFICATION OF THE CHROMOPHORE IN RETINOCHROME

Authors
SEKIYA N YOSHIHARA K
Citation
N. Sekiya et K. Yoshihara, EFFECT OF MODIFICATION OF THE CHROMOPHORE IN RETINOCHROME, Biophysical chemistry, 56(1-2), 1995, pp. 31-39
Citations number
35
Categorie Soggetti
Biophysics,Biology,"Chemistry Physical
Journal title
Biophysical chemistry → ACNP
ISSN journal
03014622
Volume
56
Issue
1-2
Year of publication
1995
Pages
31 - 39
Database
ISI
SICI code
0301-4622(1995)56:1-2<31:EOMOTC>2.0.ZU;2-W
Abstract
14-Methyl-, 14-chloro-, 14-fluoro-retinals have been incorporated into apo-retinochrome to investigate the effect of the electronegativities of C-14 substituents on the protonation of the Schiff base. The exten t of protonation decreased in going from 14-methyl- to 14-chloro- to 1 4-fluoro-retinal. There was usually no protonation in the case of the 14-fluoro analogue. The chromophore-protein interactions are also disc ussed.