Bl. Rosenzweig et al., CLONING AND CHARACTERIZATION OF A HUMAN TYPE-II RECEPTOR FOR BONE MORPHOGENETIC PROTEINS, Proceedings of the National Academy of Sciences of the United Statesof America, 92(17), 1995, pp. 7632-7636
Bone morphogenetic proteins (BMPs) are members of the transforming gro
wth factor beta superfamily. Several members of this family have been
shown to transduce their signals through binding to type I and type II
serine(threonine) kinase receptors. Here we report the cDNA cloning a
nd characterization of a human type II receptor for BMPs (BMPR-II), wh
ich is distantly related to DAF-4 a BMP type II receptor from Caenorha
bditis elegans. In transfected COS-1 cells, osteogenic protein (OP)-1/
BMP-7, and. less efficiently BMP-4, bound to BMPR-II. BMPR-II bound li
gands only weakly alone, but the binding was facilitated by the presen
ce of previously identified type I receptors for BMPs. Binding of OP-1
/BMP-7 to BMPR-II was also observed in nontransfected cell lines. More
over, a transcriptional activation signal was transduced by BMPR-II in
the presence of type I receptors after stimulation by OP-1/BMP-7.