Late-life depression ranges from mild to severe and can lead to signif
icant physical and social limitations. Up to one-third of patients wit
h medical disorders also suffer from depressive symptoms. Differential
diagnosis of depression is often confounded by medical conditions tha
t impair cognitive functioning, such as Alzheimer's disease and vascul
ar dementia. Depression is a modifiable risk factor for suicide in old
age. Once diagnosed, depression is a highly treatable disease. Treatm
ent modalities include psychotherapy, antidepressants, and electroconv
ulsive therapy for intractable cases. Many patients are now being trea
ted in primary care settings, due to managed care limits on referrals
and to patient reluctance to seek psychiatric care.