BIOADHESIVE POLYMER BUCCAL PATCHES FOR BUPRENORPHINE CONTROLLED DELIVERY - SOLUBILITY CONSIDERATION

Citation
Jh. Guo et Km. Cooklock, BIOADHESIVE POLYMER BUCCAL PATCHES FOR BUPRENORPHINE CONTROLLED DELIVERY - SOLUBILITY CONSIDERATION, Drug development and industrial pharmacy, 21(17), 1995, pp. 2013-2019
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
03639045
Volume
21
Issue
17
Year of publication
1995
Pages
2013 - 2019
Database
ISI
SICI code
0363-9045(1995)21:17<2013:BPBPFB>2.0.ZU;2-F
Abstract
By using a two-roll milling method, a new bioadhesive polymer patch fo rmulation for buprenorphine controlled delivery and consisting of poly isobutylene, polyisoprene, and Carbopol(R) 934P was prepared. Since so lubility of drug in the polymer patches is the first factor which shou ld be considered before to modify the feasibility of delivering drug t hrough the buccal mucosa, the effects of alpha-cyclodextrin, beta-cycl odextrin, sodium taurocholate, and sodium glycodeoxycholate on the sol ubility of buprenorphine were investigated, and beta-cyclodextrin was found the strongest solubility enhancer of them. The drug release prof iles were significantly affected by the drug loading and the existence of beta-cyclodextrin. Increasing the drug loading and solubility enha ncer would increase the drug release from the buccal polymer patches. The pH value change in the microenviroment of polymer patches during t he hydration of Carbopol(R) 934P could even release 20% of drug from t he polymer patches which didn't contain any solubility enhancer.