THE PREPARATION OF SUBSTITUTED HYDROXYPHENYL-PYRIDYL-ETHANOLS AND ALPHA-HYDROXYPHENYL-ALPHA-METHYLPYRIDINEETHANOLS BY THE CONDENSATION OF 2-PICOLYLLITHIUM, 3-PICOLYLLITHIUM, OR 4-PICOLYLLITHIUM WITH SELECT HYDROXY-BENZALDEHYDES AND 4-HYDROXYACETOPHENONE

Authors
KOLLER MU PEARISO KL GUION TS MARTINEZ SS BEAM CF
Citation
Mu. Koller et al., THE PREPARATION OF SUBSTITUTED HYDROXYPHENYL-PYRIDYL-ETHANOLS AND ALPHA-HYDROXYPHENYL-ALPHA-METHYLPYRIDINEETHANOLS BY THE CONDENSATION OF 2-PICOLYLLITHIUM, 3-PICOLYLLITHIUM, OR 4-PICOLYLLITHIUM WITH SELECT HYDROXY-BENZALDEHYDES AND 4-HYDROXYACETOPHENONE, Synthetic communications, 25(19), 1995, pp. 2963-2974
Citations number
42
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
19
Year of publication
1995
Pages
2963 - 2974
Database
ISI
SICI code
0039-7911(1995)25:19<2963:TPOSHA>2.0.ZU;2-K
Abstract
2-, 3-, or 4-Picolyllithium was prepared in excess lithium diisopropyl amide and condensed with several hydroxy-benzaldehydes and 4-hydroxyac etophenone to afford substituted hydroxyphenyl-pyridyl-ethanols and al pha-hydroxyphenyl-alpha-methylpyridineethanols. In two instances, 3-pi colyllithium condensed with aldehydes to presumably form the hydroxyph enyl-pyridyl-ethanol, which underwent linear dehydration to the substi tuted pyridyl-ethylenyl-phenol.