MENDELIAN INHERITANCE OF A TAQI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM DUE TO AN INSERTION IN THE HUMAN PROGESTERONE-RECEPTOR GENE AND ITS ALLELIC IMBALANCE IN BREAST-CANCER

Authors
GARRETT E ROWE SM COUGHLAN SJ HORAN R MCLINDEN J CARNEY DN FANNING M KIEBACK DG HEADON DR
Citation
E. Garrett et al., MENDELIAN INHERITANCE OF A TAQI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM DUE TO AN INSERTION IN THE HUMAN PROGESTERONE-RECEPTOR GENE AND ITS ALLELIC IMBALANCE IN BREAST-CANCER, Cancer research, therapy & control, 4(3), 1995, pp. 217-222
Citations number
25
Categorie Soggetti
Oncology
Journal title
Cancer research, therapy & control → ACNP
ISSN journal
10640525
Volume
4
Issue
3
Year of publication
1995
Pages
217 - 222
Database
ISI
SICI code
1064-0525(1995)4:3<217:MIOATR>2.0.ZU;2-3
Abstract
We have demonstrated a Mendelian pattern of inheritance for a TaqI res triction fragment length polymorphism in the human progesterone recept or gene in a single Irish pedigree. The polymorphism has been identifi ed as an insertion in intron G of the human progesterone receptor gene and a routine polymerase chain reaction assay has been developed for its detection. The distribution of the polymorphic alleles displays si gnificant (P < 0.05) deviation from Hardy-Weinberg equilibrium in brea st cancer patients.