G. Sanchezvisconti et al., AGING AND PROSTATE - AGE-RELATED-CHANGES IN ANDROGEN RECEPTORS OF EPITHELIAL-CELLS FROM BENIGN HYPERTROPHIC GLANDS COMPARED WITH CANCER, Mechanism of ageing and development, 82(1), 1995, pp. 19-29
Total and nuclear androgen receptors (AR) were studied from epithelial
cells in internal and external prostatic zones in 51- to 86-year-old
individuals with benign prostatic hyperplasia (BPH) (n = 68) and prost
atic cancer (n = 9). We focussed on the role played by androgens on th
ose processes, despite the fact that at these ages, its secretion has
normally decreased. In BPH, the nuclear AR do not change, but total me
asured androgen receptors rise with age (I = 0.5, P < 0.01). Total or
nuclear AR do not correlate with gland volume, despite its increase wi
th age (r = 0.8, P < 0.05). In prostates less than 180 cc in volume, t
here is a significant correlation between size, serum total testostero
ne level (r = 0.53, P < 0.05) and prostatic specific antigen (PSA) (r
= 0.63, P < 0.05). The amount of nuclear AR in cells from the external
zone (infiltrated by cancer or healthy) is two times greater than in
those from the internal region. Total receptor content of the external
zone cells is also high, but the sample is too small to demonstrate a
n age dependence. The results suggest that ageing is accompanied by an
accumulation of non-nuclear AR in the cytosol, that does not play a r
ole in the development of BPH because the amount of nuclear receptors
remains unaltered. The enrichment in nuclear receptors of the external
zone cells, independently of the presence of cancer, points to a grea
ter androgen dependence in these cells than in cells of the internal r
egion.