TREATMENT OF A DELAYED GRAFT FAILURE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION WITH IL-3 AND GM-CSF

We report on the partial effectiveness of sequential IL-3 and GM-CSF a dministration, following an ineffective 5-day trial with G-CSF, in a c ase of delayed graft failure after allogeneic bone marrow transplantat ion. Therapy with these growth factors was followed by a prompt (withi n 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potenti al usefulness of this growth factor schedule administration in the tre atment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.