REVEALING THE HISTORY OF INFECTIOUS-DISEASE EPIDEMICS THROUGH PHYLOGENETIC TREES

Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to t race the dynamics of viral transmission within populations. Case studi es document the worldwide spread of Human Immunodeficiency Virus type 1 (HIV-1) and hepatitis C virus (HCV). Despite similarities between th ese viruses, especially in their transmission routes, they are shown t o have very different epidemiological histories. A possible reason for the difference is that HCV has coexisted longer with human population s.