ACUTE DEPLETION OF SEROTONIN DOWN-REGULATES SEROTONIN TRANSPORTER MESSENGER-RNA IN RAPHE NEURONS

Authors
YU AQ YANG JX PAWLYK AC TEJANIBUTT SM
Citation
Aq. Yu et al., ACUTE DEPLETION OF SEROTONIN DOWN-REGULATES SEROTONIN TRANSPORTER MESSENGER-RNA IN RAPHE NEURONS, Brain research, 688(1-2), 1995, pp. 209-212
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
688
Issue
1-2
Year of publication
1995
Pages
209 - 212
Database
ISI
SICI code
0006-8993(1995)688:1-2<209:ADOSDS>2.0.ZU;2-V
Abstract
Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 day s after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsa l raphe nucleus, 5-HTT binding sites remained unchanged, suggesting th at an acute depletion of 5-HT may induce an increase in the turnover o f 5-HTT mRNA without affecting protein levels at 3 days.