AZACHLORINS - SYNTHESIS OF A NOVEL TYPE OF HYDROPORPHYRINS FROM THE BILE PIGMENT BILIRUBIN

Authors
GERLACH B MONTFORTS FP
Citation
B. Gerlach et Fp. Montforts, AZACHLORINS - SYNTHESIS OF A NOVEL TYPE OF HYDROPORPHYRINS FROM THE BILE PIGMENT BILIRUBIN, Liebigs Annalen, (8), 1995, pp. 1509-1514
Citations number
30
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
8
Year of publication
1995
Pages
1509 - 1514
Database
ISI
SICI code
0947-3440(1995):8<1509:A-SOAN>2.0.ZU;2-4
Abstract
Azachlorins rac-10a,b, rac-11, and rac-16, a novel type of hydroporphi noid compounds, were synthesized from azaporphyrins 8 and 13 by regios elective cycloaddition of singlet oxygen and further transformation by amide acetal Claisen rearrangement. The azaporphyrins are readily acc essible from the naturally occurring bile pigment bilirubin (5). The p hotophysical properties of the azachlorins recommend these chlorin der ivatives as potential photosensitizers for Photodynamic Therapy (PDT).