HEMODYNAMICS AND OXYGEN-METABOLISM IN THE PIG DURING LONG-TERM HYPOTHERMIA - COMPARISON OF 2 PH STRATEGIES

Citation
E. Kornberger et al., HEMODYNAMICS AND OXYGEN-METABOLISM IN THE PIG DURING LONG-TERM HYPOTHERMIA - COMPARISON OF 2 PH STRATEGIES, Resuscitation, 30(1), 1995, pp. 43-50
Citations number
NO
Categorie Soggetti
Emergency Medicine & Critical Care
Journal title
ISSN journal
03009572
Volume
30
Issue
1
Year of publication
1995
Pages
43 - 50
Database
ISI
SICI code
0300-9572(1995)30:1<43:HAOITP>2.0.ZU;2-P
Abstract
The aim of this study was to investigate the influence of acid-base ma nagement (pH stat or alpha stat) on hemodynamics and oxygen metabolism during long-term hypothermia in the pig. Seventeen female pigs were a nesthetized, slowly cooled to 28 degrees C with cooling mats and kept at this temperature for 36 h. Thereafter, slow rewarming was performed with inhalation of a 40 degrees C warm air/oxygen mixture and insulat ion. Eight of the 17 pigs were ventilated according to the pH stat str ategy and 9 according to the alpha stat strategy. Both groups were com pared 4 times each for hemodynamics and metabolism during cooling, hyp othermia and rewarming. The 2 strategies showed no significant differe nce in cardiac output, heart rate or mean arterial pressure. The only difference in hemodynamics was observed in mean pulmonary artery press ure and pulmonary artery resistance during hypothermia, showing higher values in pH stat animals. As for oxygen metabolism oxygen consumptio n during hypothermia was significantly higher in alpha stat animals. L ong-term hypothermia with spontaneous circulation revealed significant differences in oxygen metabolism and pulmonary artery pressure as wel l as resistance between alpha and pH stat acid-base management. These differences may be of importance when using moderate hypothermia in a clinical or experimental setting.