SYN987, SYN1193, AND SYN1253, NEW QUINOLONES HIGHLY-ACTIVE AGAINST GRAM-POSITIVE COCCI

SYN 987, 1193 and 1253 are new fluorinated quinolones with enhanced ac tivity against Gram-positive bacteria. The MICs of SYN 987, 1193 or 12 53 were studied by an agar dilution method against 88 streptococci (in cluding penicillin resistant Streptococcus pneumoniae), 30 enterococci and 62 Staphylococcus aureus. SYN 987, 1193 and 1253 were 2 to 4 time s more active than sparfloxacin and 16-64 times more active than older fluoroquinolones against all streptococci and ciprofloxacin-resistant S. aureus. This study demonstrates that SYN 987, 1193 and 1253 are ex tremely potent antibacterial agents which deserve further evaluation.