ANTIBIOTIC-INDUCED RELEASE OF ENDOTOXIN FROM ESCHERICHIA-COLI IS INHIBITED BY SALICYLATE

Authors
DOMENICO P QADRI S CUNHA BA
Citation
P. Domenico et al., ANTIBIOTIC-INDUCED RELEASE OF ENDOTOXIN FROM ESCHERICHIA-COLI IS INHIBITED BY SALICYLATE, Medical microbiology letters, 4(5), 1995, pp. 230-237
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
4
Issue
5
Year of publication
1995
Pages
230 - 237
Database
ISI
SICI code
1018-4627(1995)4:5<230:AROEFE>2.0.ZU;2-Q
Abstract
Release of endotoxin from bacteria occurs more with some antibiotics t han with others. The effect of salicylate on antibiotic-associated end otoxin release was measured in culture supernatants by the Limulus ame bocyte lysate assay. Salicylate reduced endotoxin release by antibioti cs significantly. As an adjunct to antibiotic therapy, salicylate may reduce the incidence of endotoxic shock, and may also add to the syner gy of imipenem/aminoglycoside combinations.