ABSENCE OF DETECTABLE STRIATAL DOPAMINE D-4 RECEPTORS IN DRUG-TREATEDSCHIZOPHRENIA

Authors
REYNOLDS GP MASON SL
Citation
Gp. Reynolds et Sl. Mason, ABSENCE OF DETECTABLE STRIATAL DOPAMINE D-4 RECEPTORS IN DRUG-TREATEDSCHIZOPHRENIA, European journal of pharmacology, 281(2), 1995, pp. 5-6
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
281
Issue
2
Year of publication
1995
Pages
5 - 6
Database
ISI
SICI code
0014-2999(1995)281:2<5:AODSDD>2.0.ZU;2-J
Abstract
The difference between saturable binding of [H-3]emonapride (to D-2, D -3 and D-4 receptors) and [I-125]epidepride (to D-2 and D-3 receptors) was used to determine dopamine D-4 receptors in putamen taken post-mo rtem from antipsychotic-treated schizophrenic subjects and matched con trols. Despite an overall increase in D-2/D-3 receptor density in schi zophrenia, reflecting prior antipsychotic drug treatment, striatal D-4 receptors were not significantly detectable in either controls or sch izophrenic subjects.