Gp. Reynolds et Sl. Mason, ABSENCE OF DETECTABLE STRIATAL DOPAMINE D-4 RECEPTORS IN DRUG-TREATEDSCHIZOPHRENIA, European journal of pharmacology, 281(2), 1995, pp. 5-6
The difference between saturable binding of [H-3]emonapride (to D-2, D
-3 and D-4 receptors) and [I-125]epidepride (to D-2 and D-3 receptors)
was used to determine dopamine D-4 receptors in putamen taken post-mo
rtem from antipsychotic-treated schizophrenic subjects and matched con
trols. Despite an overall increase in D-2/D-3 receptor density in schi
zophrenia, reflecting prior antipsychotic drug treatment, striatal D-4
receptors were not significantly detectable in either controls or sch
izophrenic subjects.