This paper reports the occurrence of renal disease in six young Japane
se Black cattle. Their kidneys were atrophic and of granular appearanc
e. Histologically, they exhibited interstitial fibrosis with inflammat
ory cell infiltration, clusters of atrophic and cystic tubules, and th
ickening of tubular and Bowman's basement membranes. Glomeruli were ma
rkedly reduced in numbers and were hypercellular due to mesangial prol
iferation. The affected cattle had a disease. common male ancestor, su
ggesting a familial basis for this disease. (C) 1997 W.B. Saunders Com
pany Limited.