CHROMOSOME-12 ABNORMALITIES IN MALIGNANT OVARIAN GERM-CELL TUMORS

Authors
RODRIGUEZ E MELAMED J REUTER V CHAGANTI RSK
Citation
E. Rodriguez et al., CHROMOSOME-12 ABNORMALITIES IN MALIGNANT OVARIAN GERM-CELL TUMORS, Cancer genetics and cytogenetics, 82(1), 1995, pp. 62-66
Citations number
19
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
82
Issue
1
Year of publication
1995
Pages
62 - 66
Database
ISI
SICI code
0165-4608(1995)82:1<62:CAIMOG>2.0.ZU;2-A
Abstract
We analyzed 3 cases of malignant ovarian germ cell tumors (MOGCTs), co mprising 1 dysgerminoma and 2 immature teratomas, by banded chromosome analysis and by in situ hybridization (ISH) using a chromosome 12p pa inting probe. We found evidence of 12p abnormalities in two of them. A possible common genetic pathway of origin of a subset of MOGCTs with testicular germ cell tumors (TGCTs) is discussed.