MYOSITIS AND FASCIITIS ASSOCIATED WITH GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL INFECTIONS - DEVELOPMENT OF A RABBIT MODEL

Authors
PIEPMEIER E HAMMETTSTABLER C PRICE M PETERS J KEMPER G DAVIS M
Citation
E. Piepmeier et al., MYOSITIS AND FASCIITIS ASSOCIATED WITH GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL INFECTIONS - DEVELOPMENT OF A RABBIT MODEL, The Journal of laboratory and clinical medicine, 126(2), 1995, pp. 137-143
Citations number
26
Categorie Soggetti
Medical Laboratory Technology","Medicine, General & Internal
Journal title
The Journal of laboratory and clinical medicine → ACNP
ISSN journal
00222143
Volume
126
Issue
2
Year of publication
1995
Pages
137 - 143
Database
ISI
SICI code
0022-2143(1995)126:2<137:MAFAWG>2.0.ZU;2-A
Abstract
Group A streptococci produce a variety of clinical symptoms ranging fr om minor pharyngeal infections to life-threatening soft-tissue disease . A rabbit model is described for Induction of myonecrosis and fasciit is with group A beta-hemolytic streptococci. Group A streptococcal inf ections have shown remarkable virulence in recent years, resulting in severe local tissue destruction and life-threatening toxicity. After s ubcutaneous injection into the thigh of 20 ml broth containing 10(5) t o 10(9) cfu/ml, initial soft tissue infection rapidly progressed to rh abdomyolysis. The response of the rabbits to the infection was consist ent with the human response.