A COMMUNITY TRIAL OF THE IMPACT OF IMPROVED SEXUALLY-TRANSMITTED DISEASE TREATMENT ON THE HIV EPIDEMIC IN RURAL TANZANIA .1. DESIGN

Objective: To describe the rationale and design of a randomized trial of the impact of improved services for the treatment of sexually trans mitted diseases (STD) on the incidence of HIV infection in Mwanza Regi on, Tanzania. Methods: The likely impact of improved STD treatment ser vices on HIV incidence, and the need for empirical information on the effectiveness of this intervention strategy, are discussed. The ration ale and design of such an intervention programme in Mwanza Region, and of a community-randomized trial to measure the impact of the programm e on HIV and other STD, are presented. Problems in the design and inte rpretation of the trial are reviewed. Results: Results of the baseline survey of the cohort of over 12 000 adults in 12 communities are pres ented in a companion paper. Conclusion: There is an urgent need for ef fective preventive measures against the HIV epidemic in sub-Saharan Af rica and other developing regions. Improved STD treatment has been pro moted as a potentially effective strategy, but there is little empiric al information on its impact. The trial in Mwanza Region is the first randomized study of this intervention and should provide valuable data for health policy makers.