PHYSIOLOGICAL EFFECT OF GLUCAGON IN HUMAN ISOLATED ADIPOCYTES

Authors
PEREA A CLEMENTE F MARTINELL J VILLANUEVAPENACARRILLO ML VALVERDE I
Citation
A. Perea et al., PHYSIOLOGICAL EFFECT OF GLUCAGON IN HUMAN ISOLATED ADIPOCYTES, Hormone and Metabolic Research, 27(8), 1995, pp. 372-375
Citations number
25
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone and Metabolic Research → ACNP
ISSN journal
00185043
Volume
27
Issue
8
Year of publication
1995
Pages
372 - 375
Database
ISI
SICI code
0018-5043(1995)27:8<372:PEOGIH>2.0.ZU;2-#
Abstract
In human isolated adipocytes, glucagon induces a dose dependent increm ent of the glycerol release, which is already observed at physiologica l concentrations of the hormone. Furthermore, glucagon at 10(-8) M, si gnificantly stimulates the adenylate cyclase activity in both non-solu bilized and solubilized fat plasma membranes, and at already 10(-11) M , a significant increment of the adipocyte cAMP content is observed. T hese data support previous in vivo positive results indicating that gl ucagon plays a role in human fat metabolism.