ARYL THIOCARBAMOYLATIONS OF PHTHALIDES AND X-RAY STUDIES OF 3 REACTION-PRODUCTS

Phthalides 1 have been thiocarbamoylated. We were able to isolate and characterize different reaction products formed by treatment of a mixt ure of 1 and phenyl isothiocyanate with various amounts of base. 3-Oxo -1,3-dihydro-isobenzofuran-1-carbothioic acid phenylamide 3, H-isobenz ofuranylidene)-phenylamino-methylenethio] thio-phenylamino-methylene}- 3H-isobenzofuran-1-one 4, enyl-1,3-dihydro-isobenzofuran-l-carboximido thioic acid methyl ester 5, -alkylthio-4-hydroxy-2-phenyl-2H-isoquinol in-1-one 6, and -diphenyl-3H-isobenzofuran-1,1-dicarboximidothioic aci d dimethyl ester 7 were obtained. X-ray studies have been performed in order to identify unequivocally the reaction products.