TUMOR-NECROSIS-FACTOR-ALPHA IN THE FEMALE REPRODUCTIVE-TRACT

Citation
Pf. Terranova et al., TUMOR-NECROSIS-FACTOR-ALPHA IN THE FEMALE REPRODUCTIVE-TRACT, Proceedings of the Society for Experimental Biology and Medicine, 209(4), 1995, pp. 325-342
Citations number
146
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
00379727
Volume
209
Issue
4
Year of publication
1995
Pages
325 - 342
Database
ISI
SICI code
0037-9727(1995)209:4<325:TITFR>2.0.ZU;2-L
Abstract
Tumor necrosis factor-alpha (TNF), originally identified as an inflamm ation-associated cytokine, is synthesized throughout the female reprod uctive tract as well as in placentas and embryos, Development, female sex steroid hormones, and lipopolysaccharide influence expression of t his gene, The functions of TNF may be determined in part by differenti al expression of the two species of TNF receptors, both of which seem to be regulated by female sex steroid hormones. Evidence has accumulat ed that supports a role for this potent, pleiotropic cytokine in autoc rine and paracrine processes central to reproduction, including gamete and follicle development, steroidogenesis, uterine cyclicity, placent al differentiation, development of the embryo, and parturition.