A CONVERGENT SYNTHESIS OF FUNCTIONALIZED B-SECO TAXANE SKELETONS

Authors
MONTALBETTI C SAVIGNAC M BONNEFIS F GENET JP
Citation
C. Montalbetti et al., A CONVERGENT SYNTHESIS OF FUNCTIONALIZED B-SECO TAXANE SKELETONS, Tetrahedron letters, 36(33), 1995, pp. 5891-5894
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
33
Year of publication
1995
Pages
5891 - 5894
Database
ISI
SICI code
0040-4039(1995)36:33<5891:ACSOFB>2.0.ZU;2-1
Abstract
The sequential Sonogashira cross-coupling reactions with water soluble and anhydrous Pd(0) catalysts between vinylic iodo derivatives 6, 8 a nd 3-iodocyclohexenone 7 with trimethyl silyl acetylene are used to pr oduce functionalized intermediates 11 and 18. Conjugate addition follo wed by enolate trapping with trimethyl orthoformate provided B-seco ta xane derivatives 14 and 20.